Many people found the list of signs and symptoms either useful or interesting; at least it is an emphatic way of pointing out that progesterone has so many functions it can't be considered to be just a "reproductive hormone." Since I now understand better the biological meaning of these signs, I want to emphasize more strongly the importance of normalizing nutrition, thyroid function, light exposure, and bowel action in correcting the problems behind these signs and symptoms. It is really a kind of index of physiological disorders, and it happens that progesterone is a major tool for physiological adaptation.
Abdominal bloating
Accident proneness
Acne (cyclic)
Accident proneness
Aggressiveness
Alcohol or drug addiction
Allergic rhinitis
Appetite disturbance
Arthritis(1)
Asthma especially in adolescence & menopause
Bleeding gums
Breast symptoms(2)
Bruising spontaneously, Capillary fragility
Carpal tunnel syndrome
Cold hands & feet
Conjunctival or retinal hemorrhage
Constipation, colicky pain
Colitis, regional enteritis
Depression
Diabetic vascular problems
Edema
Endometriosis, cervical dysplasia
Epilepsy, vertigo
Facial hair
Facial pallor, puffiness, darkening
Fainting
Fatigue, lethargy
Fibroids
Formication (crawling sensation on the skin)
Gall bladder symptoms
Glaucoma (high eye pressure)
Goiter
Headache, eye pain, flashes of light, photophobia
Heart murmur
High blood pressure
Hypoglycemia
Hysteria (many emotional symptoms)
Infertility
Inflammatory and "fibrous" disease
Inner ear dizziness
Insomnia
Irritability
Low blood pressure
Lethargy and clumsiness
Menopause
Mittelschmerz(3)
Migraine
Nymphomania, loss of libido
Optic neuritis
Panic, weepiness, nightworry
Palpitations or paroxysmal tachycardia
Paraesthesias
Pituitary abnormalities
Porphyria
Sciatica
Skin disorders: facial pigmentation, under the eyes erythema, urticaria
Stroke symptoms
Sweat glands: fewer functional
Toxemia of pregnancy
Fluctuations in weight
Urinary frequency, etc.
Varicose veins, tired leg
Vascular abnormalities: flushing, capillary fragility, clotting, kidney underfunction, varicosities
Katharina Dalton, The Premenstrual Syndrome and Progesterone Therapy, Year Book Medical Publishers, Inc., Chicago, 1977.
Ashley Montagu, Human Heredity, New American Library, New York, 1963.
R. F. Peat and A. L. Soderwall, "Estrogen stimulated pathway changes," Physiological Chemistry and Physics, 4 (3), 295, 1972.
R. F. Peat, "A biophysical approach to altered consciousness," J. of Orthomolecular Psychiatry, September, 1975.
S. Rose, "Environmental effects on brain and behavior," chapter in Race and Intelligence, edited by Richardson and Spears, Penguin Books, Baltimore, 1972.
A. E. Needham, The Growth Process in Animals, Van Noatrand, Princeton, NJ 1964.
Max Reiss, Psychendocrinology, Grune and Stratton, New York, 1958.